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Showing 1–6 of 6 results
Advanced filters: Author: Vishal M. Gohil Clear advanced filters

  • Many diseases are characterized by shifts in cellular energy metabolism. Gohil et al. use a quantitative, nutrient-sensitized screen to identify drugs that affect the relative rates of glycolysis and mitochondrial respiration, and demonstrate the protective capacity of an approved antiemetic in models of cardiac and cerebral ischemia.

    • Vishal M Gohil
    • Sunil A Sheth
    • Vamsi K Mootha
    Research
    Nature Biotechnology
    Volume: 28, P: 249-255

  • Mitochondrial dysfunction is linked to various rare genetic disorders and common age-related diseases, but few compounds can stimulate mitochondrial activity. Here, the authors address this issue by developing atomic vacancy-rich molybdenum disulfide nanoparticles that can catalyze intracellular reactive oxygen species to enhance mitochondrial biogenesis and cellular respiration.

    • Kanwar Abhay Singh
    • John Soukar
    • Akhilesh K. Gaharwar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.

    • Mohammad Zulkifli
    • John K. Neff
    • Vishal M. Gohil
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The uptake of calcium by mitochondria has a central role in cell physiology, and an imbalance can trigger cell death. Now the first protein that is localized to the mitochondrion and is specifically required for calcium uptake has been identified. This protein, mitochondrial calcium uptake 1 (MICU1), represents the founding member of a set of proteins required for high-capacity calcium uptake. Its discovery should aid in the full molecular characterization of the mitochondrial calcium uptake pathways.

    • Fabiana Perocchi
    • Vishal M. Gohil
    • Vamsi K. Mootha
    Research
    Nature
    Volume: 467, P: 291-296

  • This Perspective explores the connection between copper and cancer and how challenges in the field could be addressed, and is a synthesis of discussions from the Copper Cancer Consortium, a meeting of experts in the field that took place in March 2020.

    • Eva J. Ge
    • Ashley I. Bush
    • Christopher J. Chang
    Reviews
    Nature Reviews Cancer
    Volume: 22, P: 102-113