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Showing 1–4 of 4 results
Advanced filters: Author: Vishwas Mishra Clear advanced filters

  • IL-22 is considered indispensable for host defence against Citrobacter rodentium. This study reveals that dehydration is the proximate cause of mice mortality and maintaining systemic hydration allows recovery through IL-22-independent pathways.

    • Vishwas Mishra
    • Zuza Kozik
    • Gad Frankel
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Bacterial antigens, such as lipopolysaccharides, are complex structures which remain difficult to synthesise or purify for antibody generation. Here, authors present a platform technology using Citrobacter rodentium - an enteric mouse pathogen - to both produce and present complex antigens for antibody generation.

    • Joshua L. C. Wong
    • Julia Sanchez-Garrido
    • Gad Frankel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The turnover of interleukin-1β, a cytokine that plays important roles in both physiologic and pathologic inflammatory processes, is regulated by proteolytic maturation of the pro-form and by ubiquitin-mediated degradation. Here authors identify the specific ubiquitin E3 ligases that form an active complex with UBE2L3, a ubiquitin conjugating enzyme, that target pro-IL-1β for proteasomal breakdown.

    • Vishwas Mishra
    • Anna Crespo-Puig
    • Avinash R. Shenoy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16