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Showing 1–11 of 11 results
Advanced filters: Author: Vitaly Epshtein Clear advanced filters

  • An ultra-high-resolution chromatin organization map of E. coli, using Micro-C, reveals intricate chromatin structures involved in the silencing of horizontally transferred genes and those associated with active operons.

    • Alexey A. Gavrilov
    • Ilya Shamovsky
    • Evgeny Nudler
    ResearchOpen Access
    Nature
    Volume: 645, P: 1060-1070

  • UvrD acts in nucleotide excision repair by using its helicase/translocase activity to induce RNA polymerase backtracking, enabling repair enzymes to access DNA lesions.

    • Vitaly Epshtein
    • Venu Kamarthapu
    • Evgeny Nudler
    Research
    Nature
    Volume: 505, P: 372-377

  • Here, using proteomics, next-generation sequencing, biochemistry and cryo-EM, the authors delineate the role of CedA as an unconventional transcription factor in Escherichia coli, which protects from different stressors, including antibiotics, by regulating the transcriptional landscape.

    • Nikita Vasilyev
    • Mengjie M. J. Liu
    • Evgeny Nudler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 141-149

  • Transcription-Coupled DNA repair has been classically defined as the preferential repair of the template strand (TS) over the non-template strand (NTS). Here the authors challenge this classic model of TCR by using a genome-wide repair assay, CPD-seq, as well as RNA-seq, to show that TCR occurs across the entire E. coli genome – including NTS and intergenic regions.

    • Britney Martinez
    • Binod K. Bharati
    • Evgeny Nudler
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Here, using cryo-EM and biochemical methods, the authors demonstrate that second messenger (p)ppGpp regulates the bacterial RNA polymerase by binding to a site that is functionally relevant during transcriptional elongation but not initiation. Moreover, they demonstrate that binding to that site bears functional implications for nucleotide excision DNA repair and genome stability.

    • Jacob W. Weaver
    • Sergey Proshkin
    • Evgeny Nudler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 600-607

  • Rho is a general transcription termination factor in bacteria, but the mechanism by which it disrupts the RNA polymerase (RNAP) elongation complex is unknown. Here, Rho is shown to bind tightly to the RNAP throughout the transcription cycle, with the formation of the RNAP–Rho complex being crucial for termination. Furthermore, RNAP is proposed to have an active role in Rho termination through an allosteric mechanism.

    • Vitaly Epshtein
    • Dipak Dutta
    • Evgeny Nudler
    Research
    Nature
    Volume: 463, P: 245-249

  • Integrated structure–function studies show that transcription-coupled DNA repair (TCR)—rather than global genomic repair—is responsible for most chromosomal repair events in bacteria, and that TCR mainly occurs independently of the Mfd translocase.

    • Binod K. Bharati
    • Manjunath Gowder
    • Evgeny Nudler
    Research
    Nature
    Volume: 604, P: 152-159