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Showing 1–3 of 3 results
Advanced filters: Author: Vivek S. Peche Clear advanced filters

  • Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.

    • Vincenza Cifarelli
    • Sila Appak-Baskoy
    • Nada A. Abumrad
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Jacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial cell renewal and progenitor cell differentiation, due to reduced fatty acid delivery and altered lipid metabolism, and find associations between low CD36 expression and gastric diseases.

    • Miriam Jacome-Sosa
    • Zhi-Feng Miao
    • Nada A. Abumrad
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15