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Showing 1–6 of 6 results
Advanced filters: Author: Vlad S. Raducanu Clear advanced filters

  • In this work, Blair and co-authors used cryo-EM and in vitro assays to show that human Ligase 1 (Lig1) and Flap Endonuclease 1 (FEN1) form a toolbelt with the sliding clamp PCNA coordinating the sealing of Okazaki fragments.

    • Kerry Blair
    • Muhammad Tehseen
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Here, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells.

    • Vlad-Stefan Raducanu
    • Muhammad Tehseen
    • Samir M. Hamdan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structure of the human 4-subunit Pol δ bound to DNA and PCNA in a replicating state with an incoming nucleotide in the active site.

    • Claudia Lancey
    • Muhammad Tehseen
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Translesion Synthesis is a process that enables cells to overcome the deleterious effects of replication stalling caused by DNA lesions. Here the authors present a Cryo-EM structure of human Y-family DNA polymerase k (Pol k) bound to PCNA, P/T DNA and an incoming nucleotide; and propose a model for polymerase switching in which “carrier state” Pol k is recruited to PCNA.

    • Claudia Lancey
    • Muhammad Tehseen
    • Alfredo De Biasio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14