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Showing 1–3 of 3 results
Advanced filters: Author: Vladislav V. Kiselyov Clear advanced filters

  • The structure of the N-terminal Ig-superfamily (IgSF) domain of NCAM has a high similarity with the intermediate set of Ig-like domains: the first domain of the vascular cell adhesion molecule (VCAM-1), the M5 domain in titin, and telokin.

    • Niels Kirk Thomsen
    • Vladislav Soroka
    • Flemming M. Poulsen
    Correspondence
    Nature Structural Biology
    Volume: 3, P: 581-585

  • The regulation of plasma glucose levels is effected by insulin. Here, the authors reveal atomic detail of how peptides distinct from insulin bind to and activate the insulin receptor, with implications for design of small-molecule insulin mimetics.

    • Nicholas S. Kirk
    • Qi Chen
    • Michael C. Lawrence
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor activation mechanism.

    • Yibin Xu
    • Geoffrey K.-W. Kong
    • Michael C. Lawrence
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13