Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature Chemical Biology (2)
Scientific Reports (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (3)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biophysics
Cell biology
Chemical biology
Drug discovery
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–3 of 3 results

Advanced filters: Author: Volker Badock Clear advanced filters

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

Nitrile-oxide electrophiles were identified as covalent inhibitors of GPX4 that exhibit increased selectivity and reduced off-target effects relative to chloroacetamide-based inhibitors.

John K. Eaton
Laura Furst
Stuart L. Schreiber
Research30 Mar 2020
Nature Chemical Biology

Volume: 16, P: 497-506
Structural analysis of human KDM5B guides histone demethylase inhibitor development

X-ray crystallographic analyses of KDM5B provide a view of the enzyme's iron(II)- and 2-oxoglutarate-containing catalytic core, and structures of KDM5B complexes with small-molecule inhibitors reveal selectivity profiles for multiple compound chemotypes.

Catrine Johansson
Srikannathasan Velupillai
Udo Oppermann
Research23 May 2016
Nature Chemical Biology

Volume: 12, P: 539-545
A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition

Lilia Falkenstern
Victoria Georgi
Amaury Fernández-Montalván
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-21