High-frequency stimulation of the subthalamic nucleus has become a widely accepted treatment for some patients with advanced Parkinson disease. Various behavioral and cognitive adverse effects, however, have been associated with this therapeutic approach. In this Review, Volkmann and colleagues examine these detrimental neuropsychiatric effects, exploring their possible etiologies, and discussing the implications for patient management.
- Jens Volkmann
- Christine Daniels
- Karsten Witt
