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Showing 1–7 of 7 results
Advanced filters: Author: Volodymyr M. Korkhov Clear advanced filters

  • Gap junction channels formed by Cx32 enable intercellular communication, and their disruption causes CMT1X disease. Here, authors use cryo-EM and molecular dynamics simulations to show how specific lipids and sterols may directly control Cx32 channel gating

    • Pia Lavriha
    • Carina Fluri
    • Volodymyr M. Korkhov
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • Understanding how membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement—a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound—can be useful as SOI represents a green alternative to chemical synthesis. Here, the catalytic mechanism of SOI was determined using cryo-EM, EPR spectroscopy, mutagenesis, functional assays and docking experiments.

    • Basavraj Khanppnavar
    • Joel P. S. Choo
    • Xiaodan Li
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1496-1504

  • Translocation into neurons is crucial for BoNT/A1 action. Here, the authors show by single-particle cryo-EM that BoNT/A1 bound to its receptor SV2B switches its conformation from an open, translocation-incompatible to a semi-closed, translocation-competent state at acidic pH.

    • Basavraj Khanppnavar
    • Oneda Leka
    • Richard A. Kammerer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes, AC9.

    • Chao Qi
    • Pia Lavriha
    • Volodymyr M. Korkhov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.

    • Basavraj Khanppnavar
    • Julian Maier
    • Harald H. Sitte
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine its structure and show that it phosphorylates the RON complex.

    • Gaëlle Lentini
    • Rouaa Ben Chaabene
    • Dominique Soldati-Favre
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17