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Showing 1–2 of 2 results
Advanced filters: Author: Vrunda Trivedi Clear advanced filters

  • The limited infiltration and migration of T cells in the brain can hinder the success of immune checkpoint blockade in glioblastoma (GBM). Here the authors show that an adeno-associated virus-based gene therapy for the intratumor delivery of CXCL9 promotes T cell infiltration and enhances response to anti-PD1 in GBM preclinical models.

    • Christina A. von Roemeling
    • Jeet A. Patel
    • Duane A. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • This Review explains how an improved understanding of immune and nervous system interactions in the central nervous system (CNS) has guided the use of immunotherapies (including chimeric antigen receptor T cells, oncolytic viruses, cancer vaccines and immune-checkpoint inhibitors) to treat CNS tumours. The authors highlight the outcomes of clinical trials that have used immunotherapy to treat primary brain cancers and provide a perspective on future directions for the field.

    • Jasia Mahdi
    • Vrunda Trivedi
    • Michelle Monje
    Reviews
    Nature Reviews Immunology
    Volume: 26, P: 213-229