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Showing 1–14 of 14 results
Advanced filters: Author: Vyacheslav V. Kim Clear advanced filters

  • Ancient DNA reveals how the explosive expansion of Yamnaya steppe pastoralists began with a small community north of the Black Sea speaking ancestral Indo-European, and detects genetic links with Anatolian speakers, stemming from a common Indo-Anatolian homeland in the North Caucasus–lower Volga region.

    • Iosif Lazaridis
    • Nick Patterson
    • David Reich
    Research
    Nature
    Volume: 639, P: 132-142

  • Deubiquitinases (DUBs) remove ubiquitin from its target proteins. Here, authors compare the regulatory effects of the proteasome and DUBs on the ubiquitinated proteome. They find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitinated in response to DUB inhibition, which increases its enzymatic activity.

    • Fredrik Trulsson
    • Vyacheslav Akimov
    • Alfred C. O. Vertegaal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

    • Gil A. McVean
    • David M. Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 491, P: 56-65

  • The H3+ ion plays a key role in interstellar chemistry and can be formed from organic compounds upon interaction with charged particles or radiation. Here the authors demonstrate that H3+ can also be formed from water adsorbed on silica nanoparticles exposed to intense laser pulses, conditions that mimic the impact of charged particles on dust in astrophysical settings.

    • M. Said Alghabra
    • Rami Ali
    • Ali S. Alnaser
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified.

    • David T. W. Jones
    • Natalie Jäger
    • Peter Lichter
    ResearchOpen Access
    Nature
    Volume: 488, P: 100-105

  • 1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

    • Olivier Delaneau
    • Jonathan Marchini
    • Leena Peltonenz
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • Boel et al. undertake a proteomic analysis of liver, plasma, and white adipose tissue from obese patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Key protein signatures are identified across different organs that offer a proteomic biomarker panel which is more accurate than other diagnostic methods.

    • Felix Boel
    • Vyacheslav Akimov
    • Blagoy Blagoev
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-13

  • Diffractive imaging of single-particle nanoscale systems has so far been hindered by low hit probabilities and repetition rates. Here, single-particle imaging of nanospheres and viruses at megahertz repetition rates is demonstrated at the European X-ray Free-Electron Laser (XFEL) for the first time.

    • Egor Sobolev
    • Sergei Zolotarev
    • Filipe R. N. C. Maia
    ResearchOpen Access
    Communications Physics
    Volume: 3, P: 1-11