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Showing 1–2 of 2 results
Advanced filters: Author: Vyom Shah Clear advanced filters

  • uPAR is a senescence-associated protein, and CAR T cells targeting uPAR exert senolysis. Here Eskiocak et al. identify uPAR+ cells as key targets of intestinal aging and show that CAR T-mediated elimination prevents and restores age-related decline in intestinal regeneration and barrier function.

    • Onur Eskiocak
    • Joseph Gewolb
    • Corina Amor
    ResearchOpen Access
    Nature Aging
    Volume: 6, P: 108-126

  • Functional genomics and lipidomic analyses reveal that sphingolipid synthesis is required for tumour immune evasion and tumour growth in vivo, mediated in part by the impact of glycosphingolipid synthesis on cell surface expression of IFNγ receptors.

    • Mariluz Soula
    • Gokhan Unlu
    • Kıvanç Birsoy
    Research
    Nature
    Volume: 633, P: 451-458