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Showing 1–5 of 5 results
Advanced filters: Author: W. Seth Childers Clear advanced filters

  • The membrane-bound kinase CckA controls the activity of the Caulobacter crescentusmaster regulator CtrA, which in turn coordinates asymmetric cell division. Here, the authors show that CckA contains two sensory domains that have distinct sensitivities to fluctuations in cyclic-di-GMP concentration and subcellular niche.

    • Thomas H. Mann
    • W. Seth Childers
    • Lucy Shapiro
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Assembly of amyloids is important in neurodegenerative diseases, but there is limited understanding of how supramolecular chirality is controlled. Here, the authors report the design of peptide derivatives that allow chirality inversion at biologically relevant temperatures.

    • Stephen J. Klawa
    • Michelle Lee
    • Ronit Freeman
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Simple peptides are shown to assemble into well-defined amyloid phases with paracrystalline surfaces that can catalyse reactions in an enantioselective manner. Modifying individual amino acids in the building blocks enables the structure of the assembled aggregates, and the reactions that they can catalyse, to be controlled predictably.

    • Tolulope O. Omosun
    • Ming-Chien Hsieh
    • David G. Lynn
    Research
    Nature Chemistry
    Volume: 9, P: 805-809