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Showing 1–5 of 5 results
Advanced filters: Author: Walraj Gosal Clear advanced filters

  • Chemical modifications on DNA are key regulators of epigenetic function. Here, the authors develop 6-base-CUT&Tag to simultaneously profile multiple DNA and chromatin features on the same DNA fragment. This work reveals how specific DNA and histone marks colocalise at different enhancer regions.

    • Rafael de Cesaris Araujo Tavares
    • Somdutta Dhir
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • Wang et al. developed a bisulfite-free method termed DM-Seq that leverages an unnatural enzyme–substrate pair coupled with a DNA deaminase to sequence 5-methylcytosine at base resolution in sparse DNA samples, circumventing the limitations of chemical deamination methods.

    • Tong Wang
    • Johanna M. Fowler
    • Rahul M. Kohli
    Research
    Nature Chemical Biology
    Volume: 19, P: 1004-1012

  • A high-throughput mutagenesis study in a PDZ domain shows that biochemical function and adaptation primarily originate from a collectively evolving amino acid network within the structure termed a protein sector.

    • Richard N. McLaughlin Jr
    • Frank J. Poelwijk
    • Rama Ranganathan
    Research
    Nature
    Volume: 491, P: 138-142