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The visualisation of the bone metastasis process in a spatial temporal manner is lacking. Here, the authors use three-dimensional quantitative imaging and show that mouse mammary tumour cells preferentially home to endothelial subtype type H vessels within the bone marrow and remodel this vasculature by producing granulocyte-colony stimulating factor.

Therapeutic administration of angiopoietin-like 4 prevents shock during Neisseria meningitidis infection or lipopolysaccharide-induced sepsis in mice.

Pulses of adjustable duration are generated by a mode-locked random fibre laser that can drive advances in sensing. Rayleigh backscattering from cm-long sections of telecom fibre provides laser feedback and spectral selectivity to the Fourier limit.

A systematic variation of ligand properties allows an in-depth experimental and theoretical study of a highly non-canonical bonding situation in certain organic compounds, and provides insight into the criteria that must be fulfilled for such compounds to be truly considered as carbon(0)-containing entities.

Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Researchers have measured the equation of state of hydrocarbon in a high-density regime, which is necessary for accurate modelling of the oscillations of white dwarf stars.

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clinical data, that myelopoiesis is differentially regulated via M-CSF modulation in different organs at distinct stages of MS, with diet and lifestyle being potential modifiers.

Pumas are experiencing increased isolation as human persecution and habitat loss fragment the populations of this once widespread species. Here, the authors estimate the genomic consequences of this isolation by analyzing the genomes of ten pumas from across North and South America.

A heteromeric disulfide-linked complex binds to the RCR complex and is required for invasion of human erythrocytes by Plasmodium falciparum.

The Vertebrate Genome Project has used an optimized pipeline to generate high-quality genome assemblies for sixteen species (representing all major vertebrate classes), which have led to new biological insights.

This study describes a new model of eukaryotic replication termination in which converging leading strands pass each other unhindered and the replicative DNA helicase is unloaded late, after all strands have been ligated.

The phylogenetic and hybridization history of Xiphophorus fish remains contentious, despite their long-standing role as models in evolutionary biology and human disease research. This study presents a complete genome resource that resolves the previously conflicting phylogeny and evolutionary history of the group, revealing that hybridizations preceded speciation.

While the spin generation in topological insulators is well studied, little is known about the interaction of the spins with external stimuli. Here, Seifert et al. observe a helical, bias-dependent photoconductance at the lateral edges of topological Bi₂Te₂Se platelets for perpendicular incidence of light, distinct to common longitudinal photoconductance phenomena.

Forest dynamics are monitored at large scales with remote sensing, but individual tree data are necessary for ground-truthing and mechanistic insights. This study on high temporal resolution dendrometer data across Europe reveals that the 2018 heatwave affected tree physiology and growth in unexpected way.

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

A new relationship with our goods and materials would save resources and energy and create local jobs, explains Walter R. Stahel.

Xu et al. show that satellite-measured urbanicity (living in a densely populated area) is correlated with brain volume, cortical surface area and brain network connectivity in a sample of 3,867 people from China and Europe.

Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppressed phases of systemic inflammation.

Fewer than 100 wild Cat Ba langurs survive in Vietnam. Here, the authors use whole genome sequencing to demonstrate potential adaptations to saltwater consumption as well as maintenance of adaptive potential despite low levels of genetic diversity and high levels of inbreeding.

Owing to the presence of a valley degree of freedom, atomically thin transition metal dichalcogenides show promise for room temperature valleytronic applications. Here, the authors use polarization-resolved Raman spectroscopy to gain insight to the exciton-phonon coupling in charge tunable single layer MoS₂.

Ancient genome-wide data of 722 individuals and interdisciplinary analysis of large seventh- to eighth-century ce neighbouring cemeteries near Vienna are used to address the impact of the encounter between Eastern Asian Avars and Europeans.

Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this potentially fatal condition in patients using JAK inhibitors.

A multifunctional catalytic system composed of ruthenium nanoparticles immobilized on a silica surface decorated with an amine-functionalized polymer is used for the hydrogenation of biomass-derived furfural acetone and related substrates. The presence or absence of CO₂ in the gas feed alters the selectivity of the hydrogenation—producing either a ketone or a saturated alcohol, respectively—in a fully reversible manner.

Zika virus vaccination elicits Zika and dengue virus cross-neutralizing antibodies in flavivirus-exposed individuals, potentially enhancing the protective efficacy of the vaccine in flavivirus-endemic regions.

Using a combination of biochemical, structural and computational analyses, the authors unveil the mechanism of bacterial RNA polymerase pausing and restart mediated by a small-molecule-dependent RNA structural element termed a riboswitch.

Force sensing using mechanochromic polymers is currently limited to two state systems and does not allow directly correlating the force with the absorption or emission wavelength. Here, the authors present a mechanochromic donor-acceptor torsional spring that undergoes force-induced planarization during uniaxial elongation leading to force dependent red-shifted absorption and emission spectra.

Acetylation of histone lysine residues correlates with transcription activation, but it is currently debated whether histone acetylation is a cause or a consequence of transcription. Here, the authors show how global protein acetylation remains unaltered after acute inhibition of transcription, indicating that histone acetylation is not merely a consequence of transcription.

2D materials are being investigated for several applications in micro- and nanoelectronics, but their weak adhesion represents a critical challenge for device integration. Here, the authors propose a button shear testing method to evaluate the adhesion forces of various large-area 2D films on SiO₂ and Si₃N₄ substrates.

The performance of energy materials is affected by structural defects, as well as physicochemical heterogeneity over different length scales. Here the authors map nanoscale correlations between morphological and functional heterogeneity, quantifying the trap states limiting electronic transport in bismuth vanadate thin films.

ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahret al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of immune disease.

A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.

Electron cryo-microscopy revealed that ribosomes from microsporidian parasites were in a hibernating state, whereby the ribosomes form inactive pairs.

Targeting of diseased cells is key to the development of next-generation pharmaceuticals, but is often hindered by a lack of specific cell surface markers. Here the authors develop an RNA-based approach, which allows precise control of gene expression, with translation only occurring within preselected cell types of interest.

Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stability and the activity of the complex during brain development.

Exploiting optical multimodal confinement, the deep-subwavelength confinement of hyperbolic phonon polaritons is demonstrated in isotopically pure hexagonal boron nitride, enabling nanoscale polariton manipulation.

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.

Placing a single layer of tungsten diselenide in contact with twisted bilayer graphene enables superconductivity even for non-magic twist angles where insulating behavior is absent.