Excavatolide B (excB) is a marine briarane type diterpenoid with anti-inflammatory properties, however, its cellular targets and mode-of-action remain unknown. Here, the authors develop two covalent probes of excB and apply them through a chemoproteomics approach to identify STING as a direct target of excB in living mammalian cells.
- Wan-Chi Hsiao
- Guang-Hao Niu
- Mingzi M. Zhang
