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An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models

Here, the authors report the generation of a live but defective SARS-CoV-2 virus that is envelope-deficient and expresses human interferon beta. They show that nasal vaccination enhances mucosal and lung T cell response and provides pan-sarbecovirus protection in small animals.

Chun-Kit Yuen
Wan-Man Wong
Kin-Hang Kok
ResearchOpen Access24 Oct 2023
Nature Communications

Volume: 14, P: 1-18

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An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models

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