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This study quantifies infrastructure-coupled roadside solar potential across mainland China by linking transport corridors to meteorological grids and assessing electricity generation, carbon mitigation and grid-flexibility effects.

Recently field-free spin-orbit torque switching has been demonstrated in van der Waals magnetic materials. Here, taking advantage of the quantum sensing properties of spin defects in hexagonal Boron Nitride, Zhang, Zhou, and coauthors image the current-induced spin-orbit torque switching in the van der Waals magnet, Fe3GaTe2

The first data of the Jiangmen Underground Neutrino Observatory deliver high-precision neutrino oscillation parameters, improving measurements and demonstrating readiness to determine neutrino mass ordering.

This study shows that the TaMPK3 signaling pathway regulates wheat resistance to Fusarium crown rot (FCR) and reveals TaMPK3-mediated synergistic damage from FCR and drought, thereby providing a mechanistic basis for drought-aggravated FCR severity.

Reliable sweat induction remains a challenge for wearable sweat biosensing. Here, the authors develop a skin-conformal wearable device that uses ultrasound to induce sweat under resting conditions for electrochemical biomarker tracking.

Ningxia was located at a crossroads between the Eurasian Steppe and East Asia. Here, the authors sequence 89 ancient individuals to reconstructs 4,000 years of genetic history in this region.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

The authors report a hydrazine-mediated carbonyl–alkyne reductive olefination, offering a minimalist approach to structurally complex cycloolefins.

A plasmonic grating-based thermometer translates temperature into fluorescence emission angle shifts. This non-contact method achieves 0.01 °C resolution and effectively isolates thermal signals from environmental interferences.

Light-driven oxygen redox offers a new strategy to boost oxygen evolution activity by enabling direct O–O bond formation. Here, the authors report that sulfur-treated cobalt oxyhydroxide generates non-bonding oxygen states under light, enhancing oxygen evolution performance.

Achalasia is a rare condition characterised by inability to swallow. Here, the authors use whole-genome sequencing to identify a FAM129C variant associated with the disease and characterise B cell responses towards the GABA-A receptor in a mouse model expressing that variant.

Microglial CD31 is increased in Alzheimer’s disease and limits amyloid clearance. Reducing CD31 enhances Aβ degradation, alleviates pathology, and improves cognitive function in mouse models.

Telomeric systems are conserved across eukaryotes and may have originated over 1 billion years ago. Here the authors replaced yeast’s telomeres with a bacterial virus system, resulting in a stable functional assembly of DNA molecules up to 2.77 Mb, offering insights into the possible origins of telomeres.

Emerging SARS-CoV-2 variants and related sarbecoviruses rely on ACE2 for cell entry. Here, the authors identify and characterize MB-32, a benzothiazole small molecule that disrupts spike-ACE2 binding while preserving ACE2 enzymatic activity and show that MB-32 inhibits viral entry and SARS-CoV-2 infection in small animal models.

By shaping optical caustics with metasurfaces, the authors sculpt the orbital angular momentum (OAM) of light in 3D space. This strategy supports hidden OAM states, and enables multidimensional optical encryption.

The development of stable catalysts that operate under acidic conditions is important for organic acid synthesis. Herein, the authors report a strategy to dynamically attract leached Pb²⁺ species by SO₄²⁻, achieving electrosynthesis of formic acid from glucose at ampere-level current density.

The origin of asteroid (469219) Kamo‘oalewa, target of China’s Tianwen-2 mission, is debated. Here, the authors show that it probably originated from the Flora family and it resembles asteroid (25143) Itokawa-like composition but with a more space-weathered surface.

A key mechanism of immune mediated cytotoxic attack against cancer cells relies on perforin induced plasma membrane damage. This study identifies HMGCS1 driven cholesterol synthesis as a membrane repair pathway that enables tumor cell resistance to lymphocyte killing.

Deciding between partial nephrectomy (PN) or radical nephrectomy (RN) in patients with complex renal cell carcinoma (RCC) remains a significant clinical challenge. Here, the authors develop an AI model for functional risk stratification in complex RCC using preoperative computed tomography images and clinical data, aiming to assist treatment choice for complex RCC patients, for whom PN is challenging but remains feasible.

X-ray triggered molecular switches are promising for remote control through physical barriers, though it is challenging to reach the photostationary state for some radioswitches. Here the authors design a flexible radioswitching film using a triplet-triplet energy transfer system.

Li extraction from seawater is promising but challenged by low concentration and high Mg/Li ratio. Here, the authors report an integrated electrochemical system coupling Li extraction with in situ energy storage and H₂ production, upgrading seawater to a Li-rich solution with low energy consumption.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Interleukin-1 receptor-associated kinase 2 (IRAK2) is essential for Myddosome complex formation downstream of most Toll-like receptors. Here, the authors show a loss-of-function copy number variant of IRAK2 associated with immunodeficiency, autoimmunity, and autoinflammation, which disrupts IRAK2 interaction with IRAK4 and further downstream Myddosome formation, accompanied by enhanced interferon responses.

Here, the authors reported a manipulation method combining optothermal tweezers and ice water phase transition, which can achieve manipulation and assembly of particles on the interface with nanoscale precision.

Benzocyclobutenes (BCBs) represent a highly strained, privileged structural motif with significant applications in drug discovery, medicinal chemistry, organic synthesis, polymers and materials science, yet efficient synthetic methods remain limited. Here, the authors report an oxidant-free Au(I)/Au(III)-catalyzed [2 + 2] annulation strategy for the synthesis of BCBs leveraging a unique class of rationally designed hemilabile C,N-bidentate N-heterocyclic carbene ligand.

Starting with early settlements, water has long shaped the form, fate and location of cities. This study finds that preurban development in the Yangtze River Basin was tied to rivers even as it remained vulnerable to their fluctuations.

Textbook strength theories break down for van der Waals crystals. We show that flexural phonon instability triggers interlayer localized decohesion in graphite and h-BN, unmasking their unexpectedly low intrinsic van der Waals elastic limits.

Single-cell multi-omics integration across gene expression, protein abundance and chromatin accessibility remains challenging. The authors present scMAGCA, an interpretable framework for integrating these modalities, and apply it to Alzheimer’s disease and kidney cancer to identify disease-associated cell states and biomarkers.

Peripheral nerve injury lacks effective strategies for synchronous neuromuscular repair. Here, the authors develop a fully implantable self-powered mechano-electrical bioelectronic system (MEBIS) that integrates programmable mechanical stimulation with adaptive electrical signaling to enable coordinated nerve regeneration and muscle preservation, significantly improving functional recovery.

The authors report a resonant inelastic x-ray scattering study of superconducting Sm-based infinite-layer nickelate thin films. Despite the two-fold enhancement of T_c in the Sm-based nickelates compared to their Pr-based counterparts, they find that the effective in-plane exchange coupling strength is reduced by approximately 20%.

Zinc-based batteries offer safe energy storage but are limited by damaging dendrite growth. Here, authors report a zinc-specific nucleation model and a stability metric to design an advanced electrolyte that prevents dendrites, yielding highly stable, long-lasting batteries.

Neuromorphic vision sensors lack adaptive sensitivity across wide light intensities. Yang et al. report a complementary vision sensor that fuses superlinear and sublinear light-to-spike encoding in bright and dim environments, respectively, thereby enabling high robustness under challenging conditions.

Kir4.1/5.1 channels are vital for brain and kidney function. Here the authors combine structural, electrophysiological, and computational studies to reveal an inner-ring pore blockage mechanism by polyamines and inhibitors, providing the structural basis for inward rectification.

Perovskite–organic tandem solar cells promise very high efficiency, but progress is limited by voltage loss from non-radiative recombination in organic layers. Li et el. design an emission-active molecule that suppresses quenching, improves light use, and enables high efficiency tandem devices.

Ischemic stroke treatment can be complicated by brain edema if thrombolytic drugs are given too late. Here, the authors show that anisodine hydrobromide mitigates this dangerous edema in mice by targeting the Matk-Src pathway to protect blood vessels in the brain

In this study, the authors identify LRP4 as an entry receptor for Eastern equine encephalitis virus, and show that decoy proteins block infection in neuronal cells, mice, and brain organoids, and that it is conserved across birds and mammals indicating a potential role in host range and transmission.

After deep-space flight, rice seeds show increase in mutations and alteration in DNA and RNA modifications. Multi-omics and single-cell analyses suggest a transcription factor named SVT1 suppresses the differentiation of mutation-carrying cells via the MAPK pathway.

By measuring brain responses to familiar names, Wu et al. find a promising way to predict recovery in comatose ICU patients and improve outcome prediction beyond routine clinical assessment.

Tumor-associated macrophages and tumor stiffness may both support an immunosuppressive milieu in non-small cell lung cancer, but the underlying crosstalk remains unclear. Here, the authors identify macrophage-derived fibronectin as an immunosuppressive agent, both promoting extracellular matrix stiffness and inducing immunosuppressive immune cells.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Resistance to KRAS inhibitors (KRASi) remains clinically challenging. Here, the authors establish a panel of colorectal cancer organoids with differential resistance to pan-KRASi and show that it’s driven by enhancer remodelling rewiring cholesterol biosynthesis through the mevalonate pathway.

Formamidine-based perovskite solar cells promise high efficiency, but additive-induced deprotonation disrupts precursor stability and device performance. Dong et al. use a hydrolyzing ester additive to regulate proton transfer, stabilizing the precursor and achieve efficient, durable devices.

Dead metal severely inhibited the development of alkali metal batteries. Here, authors reactivated dead Na by a reverse-pulse-interspersed charging strategy, which enhanced the rate and cycle capabilities of anode-free battery, and showed wide applicability to various alkali metal batteries.

Ion motion in battery solids can deviate from classical diffusion behavior. Here, the authors use tracer exchange to reveal anomalous ion transport in LixFePO4 solids and show how surface exchange, lattice effects, and electrons shape diffusion.

The high demand of soft strain sensors requires solutions to reduce resource waste. Here, the authors propose a machine learning framework that corrects unstable signals in soft strain sensors, making them more accurate, reliable and longer-lasting, and extending their usable lifetime by more than 3,000 times.

The authors find an abrupt transition from the parent Mott insulator to a metallic state upon the introduction of an infinitesimal amount of doping in multilayer cuprate superconductors. The innermost CuO₂ planes display gapless Fermi pockets, while the second innermost planes exhibit anisotropic superconducting gaps up to ~33 meV, indicative of robust electron pairing coexisting with strong antiferromagnetic order.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Selective C–C bond activation adjacent to two heteroatoms is challenging due to competing C–X cleavage. This work develops a Ni–Al catalytic system that enables precise activation of the inert C2–C3 bond in β-lactams, facilitating efficient annulations with π-systems with high regiocontrol.