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Showing 1–5 of 5 results

Advanced filters: Author: Wanjuan Feng Clear advanced filters

Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities

Homologous recombination (HR) gene mutations are thought to be synthetic lethal with DNA polymerase theta (Polθ) inhibition. Here, the authors reveal that Polθ addiction is determined by the functional impact of gene mutations on DNA end resection activity.

John J. Krais
David J. Glass
Neil Johnson
ResearchOpen Access24 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Genetic determinants of cellular addiction to DNA polymerase theta

Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.

Wanjuan Feng
Dennis A. Simpson
Gaorav P. Gupta
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.

Megan E. Luedeman
Susanna Stroik
Dale A. Ramsden
ResearchOpen Access04 Aug 2022
Nature Communications

Volume: 13, P: 1-10
Stepwise requirements for polymerases δ and θ in theta-mediated end joining

Polymerase delta is required for multiple steps in polymerase theta-dependent repair of chromosome breaks, a pathway targeted in cancer therapy.

Susanna Stroik
Juan Carvajal-Garcia
Dale A. Ramsden
Research15 Nov 2023
Nature

Volume: 623, P: 836-841
TRAIP regulates replication fork recovery and progression via PCNA

Wanjuan Feng
Yingying Guo
Michael Shing-Yan Huen
ResearchOpen Access28 Jun 2016
Cell Discovery

Volume: 2, P: 1-14