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Showing 1–2 of 2 results
Advanced filters: Author: Wannee Limpitikul Clear advanced filters

  • Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.

    • Bonnie van Wilgenburg
    • Iris Scherwitzl
    • Paul Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Cross-reactivity to dengue virus serotypes can trigger life-threatening inflammation. Culshaw et al. show that germline-encoded components of dengue-virus-specific TCRs influence antigen engagament and suggest that ‘innate-like’ recognition of the virus might underpin harmful cross-reactivity.

    • Abigail Culshaw
    • Kristin Ladell
    • Gavin R Screaton
    Research
    Nature Immunology
    Volume: 18, P: 1228-1237