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Showing 1–3 of 3 results
Advanced filters: Author: Wardiya Afshar Saber Clear advanced filters

  • Using an unbiased phenotypic cell-based high-throughput screen, the authors identify and characterize a small molecule, BCH-HSP-C01, that restores aberrant protein trafficking in neuronal models of adapter protein complex 4 deficiency.

    • Afshin Saffari
    • Barbara Brechmann
    • Mustafa Sahin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Davies et al. identify a putative mechanism underlying the childhood neurological disorder AP-4 deficiency syndrome. In the absence of AP-4, an enzyme that makes 2-AG is not transported to the axon, leading to axonal growth defects, which can be rescued by inhibition of 2-AG breakdown.

    • Alexandra K. Davies
    • Julian E. Alecu
    • Georg H. H. Borner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • In this study, the authors show that they can induce the direct conversion of fibroblasts into nociceptor neurons via the expression of only five key transcription factors. They further confirm that these induced neurons are bona fide nociceptors by demonstrating that their expression profiles resemble that of their endogenous counterparts and show that they are responsive to common nociceptor agonists.

    • Brian J Wainger
    • Elizabeth D Buttermore
    • Clifford J Woolf
    Research
    Nature Neuroscience
    Volume: 18, P: 17-24