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Showing 1–2 of 2 results
Advanced filters: Author: Wazim Mohammed Ismail Clear advanced filters

  • The application and therapeutic success of CAR-T cell approaches are limited by the development of T cell exhaustion. Here, Stewart et al discover a role for IL-4 in driving CD8+ CAR-T cell exhaustion and demonstrate the improvement of CAR-T cell effectivity with interruption of IL-4 signalling.

    • Carli M. Stewart
    • Elizabeth L. Siegler
    • Saad S. Kenderian
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17