Nature Search

Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth

Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.

Ying Li
Hao Yu
Jian-Ming Li
Research21 Aug 2025
Nature Cancer

Volume: 6, P: 1800-1820
Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Zhe Li
Zhi-min Xu
Zhuo-wei Liu
ResearchOpen Access08 May 2024
Nature Chemical Biology

Volume: 20, P: 1341-1352
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Amendments and Corrections01 Sept 2014
Nature Genetics

Volume: 46, P: 1041
Dopamine D2 receptor regulates cortical synaptic pruning in rodents

Synaptic pruning is important during development and synaptic plasticity. Here, the authors show that the dopamine D2 receptor (Drd2) in the anterior cingulate cortex regulates synaptic pruning, affecting LTD and behaviour in transgenic rats.

Ya-Qiang Zhang
Wei-Peng Lin
Dong-Min Yin
ResearchOpen Access08 Nov 2021
Nature Communications

Volume: 12, P: 1-17
Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
Amendments and Corrections07 Mar 2018
Nature Chemical Biology

Volume: 14, P: 901
Managing China’s coal power plants to address multiple environmental objectives

China’s coal-dominated power system is a source of carbon emissions, local air pollution and water stress. This study presents three power system development scenarios that run until 2030 in China, where coal strategies are optimized under current environmental regulations and varying prices for air pollutant emissions and water.

Wei Peng
Fabian Wagner
Denise L. Mauzerall
Research13 Nov 2018
Nature Sustainability

Volume: 1, P: 693-701
Flexoelectric polarizing and control of a ferromagnetic metal

Electric polarization is well defined for insulators but not for metals. Electric-like polarization is now realized via inhomogeneous lattice strain in metallic SrRuO₃, generating a pseudo-electric field. This field affects the material’s electronic bands.

Wei Peng
Se Young Park
Daesu Lee
ResearchOpen Access17 Jan 2024
Nature Physics

Volume: 20, P: 450-455
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Colibactin is produced by human enterobacteria and assumed to be a gut bacterial genotoxin. Now, colibactin-645 has been identified as a macrocyclic colibactin metabolite that contains a C-terminal 5-hydroxy-4-oxazolecarboxylic acid moiety and induces DNA double-strand breaks in vitro and in human cell cultures via a unique copper-mediated oxidative mechanism.

Zhong-Rui Li
Jie Li
Pei-Yuan Qian
Research16 Sept 2019
Nature Chemistry

Volume: 11, P: 880-889
Homolytic H₂ dissociation for enhanced hydrogenation catalysis on oxides

Zhu et al. report a quantitative and time-resolved analysis of hydrogen activation on Ga₂O₃, specifically shedding light on the long-standing puzzle of homolytic dissociation as opposed to the heterolytic pathway on oxides.

Chengsheng Yang
Sicong Ma
Xinhe Bao
ResearchOpen Access15 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Research22 Aug 2010
Nature Genetics

Volume: 42, P: 759-763
Elevated basophils in peripheral blood predict lower extremity deep venous thrombosis in non-surgical patients with spontaneous intracerebral hemorrhage

Chu-Bin Liu
Bao-Fang Wu
Hong-Zhi Gao
ResearchOpen Access03 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
ResearchOpen Access16 Aug 2018
Nature Communications

Volume: 9, P: 1-9
Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Networking-associated genome mining on bacterial genomes followed by chemical and enzymatic analysis identified a mechanism of resistance toward nonribosomal peptide antibiotics based on hydrolytic cleavage by d-stereospecific peptidases.

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
Research26 Feb 2018
Nature Chemical Biology

Volume: 14, P: 381-387
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

Variations in pathway off-loading and module skipping within a hybrid polyketide synthase–nonribosomal peptide synthetase lead to the production of a collection of precursors to colibactin, a genotoxic compound produced by gut bacteria.

Zhong-Rui Li
Jie Li
Pei-Yuan Qian
Research22 Aug 2016
Nature Chemical Biology

Volume: 12, P: 773-775
Species sorting during biofilm assembly by artificial substrates deployed in a cold seep system

Wei Peng Zhang
Yong Wang
Pei-Yuan Qian
ResearchOpen Access17 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis

Wei-Peng Jiang
Zi-Han Sima
Tie-Jun Li
ResearchOpen Access20 Dec 2013
International Journal of Oral Science

Volume: 6, P: 31-38

Search

Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth

Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Managing China’s coal power plants to address multiple environmental objectives

Flexoelectric polarizing and control of a ferromagnetic metal

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Homolytic H₂ dissociation for enhanced hydrogenation catalysis on oxides

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Elevated basophils in peripheral blood predict lower extremity deep venous thrombosis in non-surgical patients with spontaneous intracerebral hemorrhage

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

Species sorting during biofilm assembly by artificial substrates deployed in a cold seep system

Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis

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