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Showing 1–2 of 2 results
Advanced filters: Author: Wei-Syun Huang Clear advanced filters

  • cGAS/STING activation is linked to the induction of anti-tumor immune responses. Here the authors report a role for the deubiquitinating enzyme TRABID in regulating mitotic cell division and suppressing anti-tumor immunity, suggesting that TRABID inhibition induces micronuclei and activates cGAS/STING pathway.

    • Yu-Hsuan Chen
    • Han-Hsiun Chen
    • Ruey-Hwa Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • INPP5E is shown to be involved in the process of proximal TCR signaling activation at the immune synapse by providing a preferable phosphoinositide microenvironment via hydrolyzing PI(4,5)P2 at the plasma membrane, regulating complex formation with CD3ζ, ZAP-70, and Lck, allowing proximal TCR signaling and T cell activation.

    • Tzu-Yuan Chiu
    • Chien-Hui Lo
    • Won-Jing Wang
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-17