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Cell Death & Disease (2)
Nature Communications (2)

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Showing 1–4 of 4 results

Advanced filters: Author: Weilv Xu Clear advanced filters

A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program

Here, Zhang et al. show that the gut bacterium Blautia coccoides promotes intestinal repair by activating regenerative stem cells through indole lactic acid, providing a potential therapeutic avenue for inflammatory bowel disease.

Yanan Zhang
Jinxin Meng
Shu Jeffrey Zhu
ResearchOpen Access25 Feb 2026
Nature Communications

Volume: 17, P: 1-19
Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing

Here, Zhang et al. demonstrate that the microbial metabolite indole-3-propionic acid stimulates production of β-hydroxybutyrate in intestinal cells, in turn activating regenerative stem cells to promote mucosal healing in colitis.

Yanan Zhang
Shuyu Tu
Shu Jeffrey Zhu
ResearchOpen Access06 Feb 2026
Nature Communications

Volume: 17, P: 1-21
E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

Yuhua Shi
Yang Yang
Fushan Shi
ResearchOpen Access03 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-14
Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Weilv Xu
Qiao Jin
Fushan Shi
ResearchOpen Access07 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-15