Chang et al. evaluate the movement of molnupiravir and β-d-N4- hydroxycytidine (NHC) across the blood-brain barrier (BBB) in a rat. Molnupiravir metabolizes to NHC and crosses the BBB within 20 min at approximately 0.3–0.8% of the blood-brain ratio.
- Chun-Hao Chang
- Wen-Ya Peng
- Tung-Hu Tsai