Using hiPSC, the authors report impaired ventricular specification, altered cardiac gene expression and ectopic neuronal gene expression in tetralogy of Fallot with DiGeorge syndrome cardiomyocytes (TOF-DG-hiPSC-CMs) and increased arrhythmogenicity in cardiac anisotropic sheet derived from TOF-DG-hiPSC-CMs.
- Chun-Ho Chan
- Yin-Yu Lam
- Yiu-Fai Cheung