Nature Search

Explainable SHAP- XGBoost with DAT and clinical data for freezing of gait detection in Parkinson disease

Shuxian Jin
Yumeng Qi
Ying Chang
ResearchOpen Access08 Jan 2026
npj Parkinson's Disease

P: 1-10
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Hua Bao
Shanshan Yang
Yang Shao
Research27 May 2025
Nature Medicine

Volume: 31, P: 2737-2745
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Ren et al. generate a panel of monoclonal antibodies (mAbs) that recognize distinct epitopes on the glycoprotein Gn and neutralize severe fever with thrombocytopenia syndrome virus (SFTSV) by diverse mechanisms. One most potent mAb targeting the Gn domain I provides protection against lethal SFTSV infection in mice.

Xuanxiu Ren
Jiawen Sun
Haiyan Zhao
ResearchOpen Access15 Aug 2024
Nature Communications

Volume: 15, P: 1-15
All-temperature barocaloric effects at pressure-induced phase transitions

Usually, each refrigerant has a limited refrigeration temperature span. In this work, the authors observe refrigeration with barocaloric effect in a region from 77.5 to 300 K and potentially down to 4 K.

Xueting Zhao
Zhao Zhang
Bing Li
ResearchOpen Access19 Aug 2025
Nature Communications

Volume: 16, P: 1-8
The impact of ESG performance on OFDI mode choice: the role of total factor productivity

Wenhua Yuan
Tiantian Cui
Weixiao Lu
ResearchOpen Access04 Dec 2025
Humanities and Social Sciences Communications

Volume: 13, P: 1-18
Plasticity in single-crystalline Mg₃Bi₂ thermoelectric material

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

Peng Zhao
Wenhua Xue
Qian Zhang
Research10 Jul 2024
Nature

Volume: 631, P: 777-782
High-performance ZrNiSn-based half-Heusler thermoelectrics with hierarchical architectures enabled by reactive sintering

The authors develop a scalable reactive sintering method to produce ZrNiSn-based thermoelectrics without melting, achieving a high zT of 1.33 at 873 K through hierarchical microstructure engineering and detailed property analysis.

Xin Ai
Yu Wu
Ran He
ResearchOpen Access15 Jul 2025
Nature Communications

Volume: 16, P: 1-9
Vacancy-mediated anomalous phononic and electronic transport in defective half-Heusler ZrNiBi

Vacancy has only played a stereotyped role as a scattering center in thermoelectrics, and the boundaries of its versatility have not been tested. Here, authors reveal the multifunctionality of vacancy in tailoring the phononic and electronic transport in a defective half-Heusler ZrNiBi.

Wuyang Ren
Wenhua Xue
Zhifeng Ren
ResearchOpen Access05 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Solvent-mediated charge separation drives alternative hydrogenation path of furanics in liquid water

In heterogeneous catalysis, solvents—and their interaction with metal supports—have a complex effect on reactivity. This study shows that, in Pd-catalysed furfural hydrogenation, water influences the rate and selectivity by favouring a proton transfer rather than a purely surface-bound mechanism.

Zheng Zhao
Reda Bababrik
Daniel E. Resasco
Research01 Apr 2019
Nature Catalysis

Volume: 2, P: 431-436
Early triage of critically ill COVID-19 patients using deep learning

The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern and early assessment would be vital. Here, the authors show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission.

Wenhua Liang
Jianhua Yao
Jianxing He
ResearchOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1-7
Association between albumin to Globulin ratio and pneumonia in patients with aneurysmal subarachnoid hemorrhage

Yangchun Xiao
Yu Zhang
Fang Fang
ResearchOpen Access16 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
A CRISPR–Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection

Isothermal DNA amplification techniques are useful for diagnostic applications in place of traditional PCR. Here the authors describe CRISDA, which combines CRISPR–Cas9 with strand displacement amplification and exhibits attomolar sensitivity and single-nucleotide specificity in DNA detection.

Wenhua Zhou
Li Hu
Xue-Feng Yu
ResearchOpen Access27 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Pseudoexon activating by a deep intronic variant and phenotype variation in a Chinese family with dystrophinopathy

Xingyu Xia
Kexin Jiao
Wenhua Zhu
Research30 Jun 2025
Journal of Human Genetics

Volume: 70, P: 483-488
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Understanding the fundamental nano–bio interactions of nanomaterials intended for biomedical use might unlock potential alternative applications. Here the authors reveal a tumoricidal mechanism of black phosphorus nanomaterials where these nanomaterials directly affect the mitotic centrosome machinery by suppressing polo-like kinase 1, suggesting that nanomaterials can be applied in targeted cancer therapy with their intrinsic nano–bio properties.

Ximing Shao
Zhihao Ding
Hongchang Li
Research05 Aug 2021
Nature Nanotechnology

Volume: 16, P: 1150-1160
Low-temperature sintering of Ag nanoparticles for high-performance thermoelectric module design

Connecting the different layers in thermoelectric modules is challenging. Yin et al. develop a low-temperature-sintered silver nanoparticle interlayer for high-temperature operation of devices based on a variety of thermoelectric materials.

Li Yin
Fan Yang
Qian Zhang
Research01 May 2023
Nature Energy

Volume: 8, P: 665-674
Distinguishing faceted oxide nanocrystals with ¹⁷O solid-state NMR spectroscopy

The exposed facets of oxide nanocrystals are key to their properties. Here, the authors use ¹⁷O solid-state NMR spectroscopy to discriminate between oxygen species on different facets of anatase titania nanocrystals, providing compelling evidence for the value of NMR spectroscopy in characterizing faceted oxides.

Yuhong Li
Xin-Ping Wu
Luming Peng
ResearchOpen Access18 Sept 2017
Nature Communications

Volume: 8, P: 1-6
2D CdPS₃-based versatile superionic conductors

It is difficult for solid ionic conductor to attain high conductivity for multivalent ions and at low temperature. Here authors report 2D CdPS₃ membranes with high ion conductivities for various cations (K⁺, Na⁺, Li⁺, Ca²⁺, Mg²⁺, Al³⁺) from −30 to 90 °C.

Xin Yu
Wencai Ren
ResearchOpen Access06 Jul 2023
Nature Communications

Volume: 14, P: 1-8
Deficiency of a triterpene pathway results in humidity-sensitive genic male sterility in rice

In flowering plants, the pollen coat surrounds the male germ cells and protects against dehydration, damage and pathogen attack. Here, the authors show that a deficiency in terpenoid synthesis results in rice pollen over-dehydration and leads to a humidity-sensitive conditional male sterile phenotype.

Zheyong Xue
Xia Xu
Xiaoquan Qi
ResearchOpen Access09 Feb 2018
Nature Communications

Volume: 9, P: 1-10
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe

Characterization of dynamic conformational changes in membrane protein complexes by NMR spectroscopy remains challenging. Here authors report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, which enabled the characterization of multiple conformational states of a phospho-β2 adrenergic receptor/β-arrestin-1 complex in response to different receptor ligands.

Qi Liu
Qing-tao He
Jin-peng Sun
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-17
Nanotwin-assisted grain growth in nanocrystalline gold films under cyclic loading

Nano-grained materials are known to demonstrate different physical properties to coarse grained materials, due to changes in mechanism. Here, the authors find a new mechanism, revealing that grain growth in nano-grained gold is assisted by twin formation during cyclic loading.

Xue-Mei Luo
Xiao-Fei Zhu
Guang-Ping Zhang
Research03 Jan 2014
Nature Communications

Volume: 5, P: 1-8
China's uncertain CO₂ emissions

Bing Xue
Wanxia Ren
Correspondence26 Oct 2012
Nature Climate Change

Volume: 2, P: 762
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca²⁺channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.

Chun-Hua Liu
Zheng Gong
Jin-Peng Sun
ResearchOpen Access09 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Sequence and analysis of rice chromosome 4

Qi Feng
Yujun Zhang
Bin Han
Research21 Nov 2002
Nature

Volume: 420, P: 316-320
Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and ¹⁹F-NMR

G-protein-coupled receptors (GPCRs) signal via G proteins or arrestin-mediated pathways; the plasticity of arrestin proteins is thought to underlie their function. Here, the authors use NMR to examine how β-arrestin-1 recognizes different GPCR phospho-barcodes, and how this triggers structural rearrangements to fulfill selective functions.

Fan Yang
Xiao Yu
Jin-Peng Sun
ResearchOpen Access08 Sept 2015
Nature Communications

Volume: 6, P: 1-15
ARNTL2 promotes pancreatic ductal adenocarcinoma progression through TGF/BETA pathway and is regulated by miR-26a-5p

Zhifang Wang
Tingting Liu
Tingting Wang
ResearchOpen Access10 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-16
Atomic-scale configurations of synchroshear-induced deformation twins in the ionic MnS crystal

Y. T. Zhou
Y. B. Xue
X. L. Ma
ResearchOpen Access30 May 2014
Scientific Reports

Volume: 4, P: 1-6
The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults

Yue Liu
Donglin Zhang
Mingyang Wu
ResearchOpen Access24 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Norepinephrine inhibits CD8⁺ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma

Qishun Geng
Lifeng Li
Jie Zhao
ResearchOpen Access16 Jan 2023
British Journal of Cancer

Volume: 128, P: 1223-1235
Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Shaobo Wang
Yanhua Qi
Gang Li
ResearchOpen Access03 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-17
Minor stroke patients with mild-moderate diastolic blood pressure derive greater benefit from dual antiplatelet therapy

Tingting Liu
Yongle Wang
Xiaoyuan Niu
ResearchOpen Access05 Sept 2023
Hypertension Research

Volume: 47, P: 291-301
NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Guizhen Zhang
Liwen Liu
Guangying Cui
ResearchOpen Access01 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-14
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC

Longhao Wang
Tao Hu
Jie Zhao
ResearchOpen Access10 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-16
Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage

Xiao Gao
Ye Xiong
Gang Li
ResearchOpen Access13 May 2020
Cell Death & Disease

Volume: 11, P: 1-16
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma

Lifeng Li
Li Yang
Yi Zhang
ResearchOpen Access22 May 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-15
Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

Xiaofan Guo
Wei Qiu
Gang Li
Research01 May 2018
Oncogene

Volume: 37, P: 4239-4259
A novel constraint-based structure learning algorithm using marginal causal prior knowledge

Yifan Yu
Lei Hou
Fuzhong Xue
ResearchOpen Access20 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
SHAP based predictive modeling for 1 year all-cause readmission risk in elderly heart failure patients: feature selection and model interpretation

Hao Luo
Congyu Xiang
Rongchuan Yue
ResearchOpen Access31 Jul 2024
Scientific Reports

Volume: 14, P: 1-15
Mechanism study on the sulfidation of ZnO with sulfur and iron oxide at high temperature

Junwei Han
Wei Liu
Wenqing Qin
ResearchOpen Access10 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo

Jiali Wan
Jia-Hong Wang
Wenhua Li
ResearchOpen Access22 Jun 2015
Scientific Reports

Volume: 5, P: 1-16
Development and validation of a machine learning-based readmission risk prediction model for non-ST elevation myocardial infarction patients after percutaneous coronary intervention

Yanxu Liu
Linqin Du
Rongchuan Yue
ResearchOpen Access11 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56

Min Xue
Kai Zhang
Ting Zhuang
ResearchOpen Access18 Apr 2019
Oncogenesis

Volume: 8, P: 1-14
Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization

Ji Yan
Shu Zhang
Fang Peng
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Maximakinin reduced intracellular Ca²⁺ level in vascular smooth muscle cells through AMPK/ERK1/2 signaling pathways

Yang Yu
Xue-qian Wu
Cheng Xu
Research01 Jun 2023
Hypertension Research

Volume: 46, P: 1949-1960
Geographical distribution of the dispersal ability of alien plant species in China and its socio-climatic control factors

Quanlai Zhou
Jing Wu
Yongcui Wang
ResearchOpen Access30 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma

Kang-Shuai Li
Xiao-Dong Zhu
Hui-Chuan Sun
ResearchOpen Access07 May 2020
Cell Death & Disease

Volume: 11, P: 1-15
An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants

Minjie Cao
Xue Liu
Yong Xu
ResearchOpen Access09 Jul 2013
Cell Research

Volume: 23, P: 1043-1054
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members

Xiaodong Xue
Jian Zhang
Huishan Wang
ResearchOpen Access02 Aug 2017
Scientific Reports

Volume: 7, P: 1-16
Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

Liming Yu
Bing Gong
Huishan Wang
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Macrophage Dicer promotes tolerogenic apoptotic cell clearance and immune tolerance by inhibiting pentose phosphate pathway activity

Qiangdongzi Mao
Bangwei Luo
Zhiren Zhang
CorrespondenceOpen Access18 May 2021
Cellular & Molecular Immunology

Volume: 18, P: 1841-1843
Myocardial Deformation in Cardiac Amyloid Light-chain Amyloidosis: Assessed with 3T Cardiovascular Magnetic Resonance Feature Tracking

Rui Li
Zhi-gang Yang
Ying-kun Guo
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-9

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