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Showing 1–2 of 2 results
Advanced filters: Author: Wenning Zhu Clear advanced filters

  • The SARS-CoV-2 papain-like protease (PLpro) is of interest as a drug target. Here, the authors identify GRL0617 as a PPI (protein–protein interaction) inhibitor of SARS-CoV-2 PLpro that inhibits its deISGylating activity and present the mechanism of action of the compound through the GRL0617-bound PLpro crystal structure and NMR studies.

    • Ziyang Fu
    • Bin Huang
    • Hao Huang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.

    • Tao Yu
    • Yongjin J. Zhou
    • Florian David
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11