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Showing 1–5 of 5 results
Advanced filters: Author: Wenshe Ray Liu Clear advanced filters

  • Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H3K14 promotes acetylation of H3K23 by this complex to activate transcription.

    • Brianna J. Klein
    • Suk Min Jang
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for the engagement with the nucleosome and their association with DNA is essential for transcriptional regulation.

    • Brianna J. Klein
    • Jordan T. Feigerle
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.

    • Jeffery M. Tharp
    • J. Trae Hampton
    • Wenshe Ray Liu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14