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Showing 1–4 of 4 results

Advanced filters: Author: Wenyong Fan Clear advanced filters

Engineered thoracic spinal cord organoids for transplantation after spinal cord injury

Thoracic vertebral segment-specific spinal cord organoids transplanted in a spinal cord injury mouse model can precisely match the transplantation site, establish synaptic connections, enhance in vivo neuroelectric conduction and restore motor function.

Yanjing Zhu
Ruiqi Huang
Rongrong Zhu
ResearchOpen Access24 Oct 2025
Nature Biomedical Engineering

P: 1-21
Clinicopathological significance of Kruppel-like factor 15 and epithelial-to-mesenchymal transition related factors in bladder cancer

Wenyong Li
Rudi Lv
Sheng Xue
ResearchOpen Access06 Nov 2025
Scientific Reports

Volume: 15, P: 1-9
Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

TIGIT is a co-inhibitory receptor associated with T cell exhaustion. Tian and colleagues demonstrate that TIGIT is the predominant inhibitory receptor on NK cells in both humans and mice and that its blockade enhances NK cell–dependent rejection of tumors in experimental models.

Qing Zhang
Jiacheng Bi
Zhigang Tian
Research18 Jun 2018
Nature Immunology

Volume: 19, P: 723-732
FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma

How serine synthesis is regulated in cancer remains to be further explored. Here the authors identify FBXO7, an E3 ubiquitin ligase, inhibits serine synthesis in hepatocellular carcinoma by promoting ubiquitination and degradation of PRMT1 methyltransferase.

Li Luo
Xingyun Wu
Kui Wang
ResearchOpen Access05 Jun 2024
Nature Communications

Volume: 15, P: 1-15