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Showing 1–3 of 3 results
Advanced filters: Author: Wenze Niu Clear advanced filters

  • Expression of the transcription factor SOX2 reprogrammes astrocytes into neuroblasts in the adult mouse striatum. Here, the authors use the same approach in the injured adult mouse spinal cord to convert resident astrocytes into neuroblasts that can mature into synapse-forming neurons.

    • Zhida Su
    • Wenze Niu
    • Chun-Li Zhang
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Adult differentiated cells can be reprogrammed to lineage-restricted proliferating neural precursors in vitro. Zhang and colleagues show that the transcription factor SOX2 is sufficient to reprogram resident astrocytes in the mouse brain to neuroblasts that can proliferate and differentiate following treatment with histone deacetylase inhibitors and differentiating factors BDNF and noggin.

    • Wenze Niu
    • Tong Zang
    • Chun-Li Zhang
    Research
    Nature Cell Biology
    Volume: 15, P: 1164-1175