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Showing 1–2 of 2 results
Advanced filters: Author: Wenzel M. Hackeng Clear advanced filters

  • Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.

    • Michaël Noë
    • Noushin Niknafs
    • Laura D. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.

    • Paloma Cejas
    • Yingtian Xie
    • Henry W. Long
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11