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Showing 1–8 of 8 results

Advanced filters: Author: Werner Geldenhuys Clear advanced filters

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

Chemoresistance and relapse are main limitations in the treatment of acute lymphoblastic leukemia (ALL). Here, the authors identify Quinacrine (QC) as a sensitizer for Cytarabine (AraC) and establish a QC-CASIN regimen to improve leukemia eradication in ALL.

Limei Wu
Srinivas Chatla
Wei Du
ResearchOpen Access26 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Co-culture model of B-cell acute lymphoblastic leukemia recapitulates a transcription signature of chemotherapy-refractory minimal residual disease

Stephanie L. Rellick
Gangqing Hu
Laura F. Gibson
ResearchOpen Access04 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations

Using inducible transgenic mouse models, Joffin, Gliniak and colleagues demonstrate that altering mitochondrial iron levels in adipose tissue macrophages has profound effects on systemic metabolism in male mice.

Nolwenn Joffin
Christy M. Gliniak
Philipp E. Scherer
Research03 Nov 2022
Nature Metabolism

Volume: 4, P: 1474-1494
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand

MitoNEET is an iron-sulfur protein found in the outer mitochondrial membrane and implicated in several metabolic disorders. Here the crystal structure of mitoNEET with a bound sulfonamide ligand is reported and used to design new mitoNEET ligands.

Werner J. Geldenhuys
Timothy E. Long
Aaron R. Robart
ResearchOpen Access03 Jul 2019
Communications Chemistry

Volume: 2, P: 1-9
Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency

Benjamin Mitchell
Chloe Coulter
Ezequiel M. Salido
ResearchOpen Access15 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis

Allison L. Brichacek
Stanley A. Benkovic
Candice M. Brown
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-19
LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

Yuriy V. Loskutov
Caryn L. Griffin
Elena N. Pugacheva
Research11 Jan 2018
Oncogene

Volume: 37, P: 1457-1471
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling

Gregory R Sondag
Thomas S Mbimba
Fayez F Safadi
ResearchOpen Access02 Sept 2016
Experimental & Molecular Medicine

Volume: 48, P: e257