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Showing 1–3 of 3 results
Advanced filters: Author: Wesley D. Gifford Clear advanced filters
  • A rare cell subpopulation within mouse embryonic stem cell cultures is identified that exhibits properties of two-cell (2C) embryos; the interconversion of ES cells to 2C cells correlates with endogenous retroviral activity.

    • Todd S. Macfarlan
    • Wesley D. Gifford
    • Samuel L. Pfaff
    Research
    Nature
    Volume: 487, P: 57-63
  • Differentiated cells can be reprogrammed into induced pluripotent stem (iPS) cells through the transient overexpression of a small number of transcription factors. These iPS cells resemble embryonic stem (ES) cells but, until now, they had not passed the most stringent test of pluripotency by generating full-term or adult mice in tetraploid complementation assays. Here, fertile adult mice derived entirely from iPS cells are reported.

    • Michael J. Boland
    • Jennifer L. Hazen
    • Kristin K. Baldwin
    Research
    Nature
    Volume: 461, P: 91-94