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Showing 1–13 of 13 results
Advanced filters: Author: Will J. Gibson Clear advanced filters

  • Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze the final step of lysine catabolism in plants.

    • Mitchell G. Thompson
    • Jacquelyn M. Blake-Hedges
    • Jay D. Keasling
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The immune receptor Transmembrane and immunoglobulin domain containing 2 (TMIGD2) mediates T-cell and nature killer cells co-stimulation upon B7-family HHLA2 engagement. Here, the authors show that TMIGD2 is expressed in Acute Myeloid Leukaemia stem cells regulating self-renewal and differentiation to facilitate leukemogenesis.

    • Hao Wang
    • R. Alejandro Sica
    • Xingxing Zang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • The authors demonstrate in vitro CRISPR/CAS9-mediated editing of the canine adenovirus type 2 (CAV2) genome to successfully insert a red fluorescent protein reporter construct and to replace E3 gene sequences with a single domain antibody in the CAV2 genome. This work provides a significantly improved and efficient method for targeted editing of adenoviruses to generate altered and potentially therapeutic viral genomes in the shortest possible time.

    • Abdul Mohin Sajib
    • Payal Agarwal
    • Bruce F. Smith
    Research
    Laboratory Investigation
    Volume: 101, P: 1627-1636

  • The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-14

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218

  • It is now feasible to dissect the influence of the environment on gene function in many species — a desirable goal from a biomedical, agricultural and evolutionary perspective. This article describes the progress made so far, and the analytical challenges to be overcome.

    • Greg Gibson
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 575-581

  • Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

    • Montserrat Garcia-Closas
    • Fergus J Couch
    • Peter Kraft
    Research
    Nature Genetics
    Volume: 45, P: 392-398

  • IBS is a common disorder that can have an enormous negative effect on patients and society as a whole; however, many patients do not achieve adequate symptom relief with the currently available therapies. In this Review, Magnus Halland and Nicholas Talley discuss the latest treatments for IBS, including novel nonpharmacological and pharmacological approaches.

    • Magnus Halland
    • Nicholas J. Talley
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 13-23