This paper shows that in response to treatment of mice with interferon-α (IFNα), haematopoietic stem cells exit the dormant stage and enter an active cell cycle, The data may help to clarify the clinical effects of IFNa on leukaemic cells, and raise the possibility for new applications of type I interferons to target cancer stem cells.
- Marieke A. G. Essers
- Sandra Offner
- Andreas Trumpp
