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Showing 1–14 of 14 results
Advanced filters: Author: William J. Sandborn Clear advanced filters

  • Important advances have been made in the management of IBD in 2011. Research has focused on optimizing the currently available therapies and taking a more tailored approach to each individual patient.

    • Guillaume P. Pineton de Chambrun
    • William J. Sandborn
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 70-72

  • Endoscopic assessment in IBD provides direct visualization of the affected bowel mucosa. There is an important need for the meaningful measurement of these endoscopic images at the correct time point for medical decision-making and for clinical trials. European guidelines on endoscopy in IBD have recently been published.

    • Reena Khanna
    • Barrett G. Levesque
    • William J. Sandborn
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 9-10

  • Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease.

    • Debashis Sahoo
    • Lee Swanson
    • Pradipta Ghosh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Metabolomics data from germ-free and specific-pathogen-free mice reveal effects of the microbiome on host chemistry, identifying conjugations of bile acids that are also enriched in patients with inflammatory bowel disease or cystic fibrosis.

    • Robert A. Quinn
    • Alexey V. Melnik
    • Pieter C. Dorrestein
    Research
    Nature
    Volume: 579, P: 123-129

  • This study demonstrates the activation of a STAT3-independent healing pathway in response to mucosal injury which involves the co-receptor for IL-6 cytokines gp130 and downstream effectors Src, Yes, YAP and Notch.

    • Koji Taniguchi
    • Li-Wha Wu
    • Michael Karin
    Research
    Nature
    Volume: 519, P: 57-62

  • IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL-12 and/or IL-23.

    • Bram Verstockt
    • Azucena Salas
    • Stefania Vetrano
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 433-446

  • Biosimilar monoclonal antibodies (mAbs) to TNF are being developed that are highly similar, but not identical to the innovator molecules. CT-P13, a biosimilar of infliximab, is the first anti-TNF mAb to get approval in South Korea, Europe and Canada. However, uncertainties remain about indication extrapolation and interchangeability.

    • Niels Vande Casteele
    • William J. Sandborn
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 373-374

  • Members of the integrin family of receptors, which are involved in cell–cell adhesion, have been successfully targeted for cardiovascular disease, multiple sclerosis and inflammatory bowel disease. Ley and colleagues review the biological basis for the development of the next generation of integrin-targeted drugs, highlighting lessons learned from successes and failures.

    • Klaus Ley
    • Jesus Rivera-Nieves
    • Sanford Shattil
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 173-183

  • Obesity affects 15–40% of patients with IBD. Here, Singh and colleagues discuss the evidence linking obesity to IBD pathogenesis, the effect of obesity on disease outcomes and treatment response, and obesity-related issues in abdominal imaging and IBD surgery.

    • Siddharth Singh
    • Parambir S. Dulai
    • William J. Sandborn
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 110-121

  • Intestinal immune cell trafficking is a tightly regulated process involved in health and disease. This Review discusses the sphingosine 1-phosphate modulators as therapeutic agents in targeting leukocyte trafficking and inflammation in inflammatory bowel disease.

    • Bram Verstockt
    • Stefania Vetrano
    • Severine Vermeire
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 351-366