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Nature Microbiology (2)
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Showing 1–3 of 3 results

Advanced filters: Author: William Riedl Clear advanced filters

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

ISG15 conjugation is essential to activate the RIG-I-like receptor MDA5 and trigger antiviral responses. SARS-CoV-2 suppresses MDA5 activation by direct PLpro-mediated de-ISGylation to escape innate immunity.

GuanQun Liu
Jung-Hyun Lee
Michaela U. Gack
Research16 Mar 2021
Nature Microbiology

Volume: 6, P: 467-478
Tau deposition is associated with functional isolation of the hippocampus in aging

Deposition of tau protein aggregates occurs during aging and Alzheimer disease. Here, the authors show that tau burden in the anterior-temporal memory network is associated with disrupted fMRI connectivity and functional isolation of the hippocampus from other memory network components.

Theresa M. Harrison
Anne Maass
William J. Jagust
ResearchOpen Access25 Oct 2019
Nature Communications

Volume: 10, P: 1-12
Dusting for flu’s fingerprints

A key step of the antiviral immune response is detection of the viral intruder. Infection with highly pathogenic strains of influenza virus is now shown to produce short aberrant viral RNAs that potently trigger activation of innate immunity.

William Riedl
Michaela U. Gack
News & Views24 Oct 2018
Nature Microbiology

Volume: 3, P: 1196-1197