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Showing 1–7 of 7 results
Advanced filters: Author: William W. Navarre Clear advanced filters

  • Here, combining metabolomic, proteomic and biophysical analyses, the authors identify and characterize a series of diindole molecules produced from commensal bacteria metabolites that act as specific agonists for the orphan constitutive androstane receptor (CAR), having potential to modulate gut and liver inflammation, metabolic diseases and cancer.

    • Jiabao Liu
    • Ainaz Malekoltojari
    • Henry M. Krause
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • PoxA is a lysyl-tRNA synthetase paralog that post-translationally modifies elongation factor P (EF-P) with a lysine moiety. Further biochemical analysis reveals that (R)-β-lysine, rather than the more abundant α-amino acid, is the preferred substrate for PoxA.

    • Hervé Roy
    • S Betty Zou
    • Michael Ibba
    Research
    Nature Chemical Biology
    Volume: 7, P: 667-669

  • It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.

    • Thergiory Irrazabal
    • Bhupesh K. Thakur
    • Alberto Martin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

    • Jennifer Wessel
    • Audrey Y Chu
    • Mark O Goodarzi
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16

  • Zahedivash et al. undertake a single center retrospective analysis of patients less than 18 years of age with history of an arrhythmia to determine whether a wearable device can capture arrhythmias. Arrhythmias are identified in 28% of patients, mainly the difficult to identify supraventricular tachycardias.

    • Aydin Zahedivash
    • Henry Chubb
    • Scott R. Ceresnak
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-7