The putative tumour suppressor LKB1/XEEK1 (Xenopus egg and embryo kinase 1) has been implicated in many cellular processes and signalling pathways. Now, XEEK1 is found to exist in a complex with GSK3 (glycogen synthase kinase 3) and protein kinase C ζ (PKCζ), resulting in increased Wnt signal transduction during embryonic development. This discovery positions XEEK1 as a potential intersection point for crosstalk between Wnt and other pathways.
- Wilson K. Clements
- David Kimelman
