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Showing 1–4 of 4 results
Advanced filters: Author: Wim Burmeister Clear advanced filters

  • Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its cellular receptor human desmoglein 2, which reveals residues critical for HAd-receptor interactions.

    • Emilie Vassal-Stermann
    • Gregory Effantin
    • Pascal Fender
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • The human colony-stimulating factor (hCSF-1) cytokine is essential for innate and adaptive immune responses. The Epstein-Barr virus protein BARF1 binds to hCSF-1, preventing interferon-α secretion. Structural and functional data reveal a new mechanism for the antagonism of human but not mouse CSF-1 signaling by BARF1.

    • Jonathan Elegheert
    • Nathalie Bracke
    • Savvas N Savvides
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 938-947

  • The catalytic subunit E9 of the vaccinia virus DNA polymerase forms a functional polymerase holoenzyme by interacting with the heterodimeric processivity factor A20/D4. Here the authors present the structure of full-length E9 and show that an insertion within its palm domain binds A20, in a mode different from other family B polymerases.

    • Nicolas Tarbouriech
    • Corinne Ducournau
    • Frédéric Iseni
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137