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Structure and function of the EA1 surface layer of Bacillus anthracis

S-layers form continuous protein lattices on the surface of bacteria. Here, authors use S-layer depolymerizing nanobodies to solve the structure of the EA1 S-layer in the pathogen Bacillus anthracis and show its role as cell wall supportive structure”

Adrià Sogues
Antonella Fioravanti
Han Remaut
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-13
A dual-constriction biological nanopore resolves homonucleotide sequences with high fidelity

Equipping a protein nanopore with a second constriction improves sequencing of homopolymer DNA stretches.

Sander E. Van der Verren
Nani Van Gerven
Han Remaut
Research06 Jul 2020
Nature Biotechnology

Volume: 38, P: 1415-1420
Nucleation and growth of a bacterial functional amyloid at single-fiber resolution

AFM is used to show that curli, the functional amyloid fibrils generated by bacteria, form by polar growth from a one-step nucleation of monomers into minimal fibril units without transitioning through an intermediate, non-amyloid oligomeric state.

Mike Sleutel
Imke Van den Broeck
Han Remaut
Research19 Jun 2017
Nature Chemical Biology

Volume: 13, P: 902-908
Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

The use of nanobodies that inhibit the self-assembly of the S-layer protein Sap from B. anthracis enabled the elucidation of the structure of this protein. The nanobodies also trigger disintegration of assembled S-layers and attenuate both bacterial growth and anthrax pathology in animal models of infection.

Antonella Fioravanti
Filip Van Hauwermeiren
Han Remaut
Research15 Jul 2019
Nature Microbiology

Volume: 4, P: 1805-1814
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

CsgG and CgsE form an encaging translocon for selective, iterative diffusion of curli subunits across the non-energized bacterial outer membrane.

Parveen Goyal
Petya V. Krasteva
Han Remaut
Research14 Sept 2014
Nature

Volume: 516, P: 250-253

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Structure and function of the EA1 surface layer of Bacillus anthracis

A dual-constriction biological nanopore resolves homonucleotide sequences with high fidelity

Nucleation and growth of a bacterial functional amyloid at single-fiber resolution

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

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