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Showing 1–12 of 12 results
Advanced filters: Author: Wing Fuk Chan Clear advanced filters

  • SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

    • Biao Zhou
    • Runhong Zhou
    • Zhiwei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

    • Shuofeng Yuan
    • Xin Yin
    • Kwok-Yung Yuen
    Research
    Nature
    Volume: 593, P: 418-423

  • During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose may underlie its ability to rapidly transmit throughout a population.

    • Bobo Wing-Yee Mok
    • Honglian Liu
    • Honglin Chen
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-8

  • Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in golden Syrian hamster.

    • Hanjun Zhao
    • Kelvin K. W. To
    • Kwok-Yung Yuen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

    • Hin Chu
    • Bingjie Hu
    • Kwok-Yung Yuen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but reduced immunopathology in a hamster model of infection.

    • Pui Wang
    • Siu-Ying Lau
    • Honglin Chen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Current vaccines are less efficient in preventing infection. Here, the authors show that an intranasal vaccine (DelNS1-RBD) based on a live attenuated influenza virus induces robust levels of neutralizing antibodies and T cells and prevents replication of SARS-CoV-2 Delta and Omicron variants in respiratory tissues.

    • Shaofeng Deng
    • Ying Liu
    • Honglin Chen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Some immune cells undergo processes that pose unique challenges to the 3D organization of their genomes. These include antigen receptor rearrangement, clonal expansion and the contortion of their nuclei. Here, Allan and colleagues discuss the latest insights into these processes from a structural genomics perspective.

    • Timothy M. Johanson
    • Wing Fuk Chan
    • Rhys S. Allan
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 448-456