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Showing 1–7 of 7 results

Advanced filters: Author: Wioletta Rut Clear advanced filters

SARS-CoV-2 M^pro inhibitors and activity-based probes for patient-sample imaging

Screening for substrate preference of the SARS-CoV and SARS-CoV-2 main protease M^pro leads to the development of activity-based probes useful for structural analysis and for visualization of active M^pro in infected patient epithelial cells.

Wioletta Rut
Katarzyna Groborz
Marcin Drag
Research22 Oct 2020
Nature Chemical Biology

Volume: 17, P: 222-228
Chemical tools to define and manipulate interferon-inducible Ubl protease USP18

USP18 is a multifunctional cysteine protease involved in IFN pathways. Here, the authors report chemical probes and chemoproteomics platforms that allow to detect and perturb USP18 activity in complex biological systems with the potential to unravel important (de)ISGylation-dependent processes.

Griffin J. Davis
Anthony O. Omole
Euna Yoo
ResearchOpen Access22 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

Reinke et. al. show that targeting host proteins like cathepsins is a promising strategy for treating SARS-CoV-2 and other viral infections due to their mutational stability in contrast to highly mutable viral targets.

Patrick Y. A. Reinke
Edmarcia Elisa de Souza
Alke Meents
ResearchOpen Access18 Oct 2023
Communications Biology

Volume: 6, P: 1-13
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL^pro and M^pro proteases, and nsp14 guanine N7-methyltransferase

Mikolaj Zmudzinski
Wioletta Rut
Marcin Drag
ResearchOpen Access06 Jun 2023
Scientific Reports

Volume: 13, P: 1-16
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Daniel Jan Strub
Michał Talma
Marcin Drąg
ResearchOpen Access20 Aug 2022
Scientific Reports

Volume: 12, P: 1-14
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Marcin Poreba
Wioletta Rut
Marcin Drag
Research11 Apr 2019
Cell Death & Differentiation

Volume: 26, P: 2695-2709
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

Marcin Poreba
Aleksandra Szalek
Marcin Drag
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-13