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Showing 1–6 of 6 results
Advanced filters: Author: Wout Oosterheert Clear advanced filters
  • Release of inorganic phosphate (Pi) from actin marks older actin filaments for disassembly. Here, the authors show how Pi exits the F-actin interior through a ‘molecular backdoor’. The backdoor arrangement is distorted in a disease-linked actin variant.

    • Wout Oosterheert
    • Florian E. C. Blanc
    • Stefan Raunser
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1774-1785
  • Cryo-electron microscopy structures of skeletal F-actin show solvent-driven rearrangements governing actin filament assembly and aging with potential application in design of drugs and small molecules for imaging and therapy.

    • Wout Oosterheert
    • Björn U. Klink
    • Stefan Raunser
    ResearchOpen Access
    Nature
    Volume: 611, P: 374-379
  • Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe3+ and Cu2+ ions to facilitate metal-ion uptake by mammalian cells. Here, authors employ single-particle cryo-EM to gain insights into the molecular principles of iron reduction by human STEAP4 .

    • Wout Oosterheert
    • Laura S. van Bezouwen
    • Piet Gros
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9