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Measurements of the electronic structure of a trilayer cuprate superconductor suggest that its high critical temperature is explained by the different doping levels of the layers. The combination of underdoped inner layer and overdoped outer layers supports superconductivity.

Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathogenic particles from the airspace.

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G₁₁ and G_o, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Magnesium rechargeable batteries potentially offer high-energy density, safety, and low cost. Here the authors show a battery that reversibly intercalates magnesium monochloride cations with excellent rate and cycle performances in addition to the large capacity.

Measurements of the proton’s generalized spin polarizabilities provide discriminating power between effective descriptions of the strong interaction at low energy.

Targeting CDK4/6 in breast cancer has been demonstrated to be initially effective but often, resistance develops. Here, the authors identify microphthalmia-associated transcription factor-A (MITF-A) as a driver of CDK4/6 inhibitor resistance in breast cancer and show that MITF-A activity is mediated through O-GlcNAcylation at Serine 49, promoting its nuclear import.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

To understand the anomalous electronic transport properties of ZrTe₅ remains an elusive puzzle. Here, Zhang et al. report direct electronic evidence to the origin of the resistivity anomaly and temperature induced Lifshitz transition in ZrTe₅, indicating it being a weak topological insulator.

Thermoelectric clathrates host guest atoms that can rattle inside their surrounding cages, yielding unusual phononic properties. Ikeda et al. show that ab initio calculations fail to account for thermodynamic and thermal transport data and propose a Kondo-like mechanism to explain the discrepancy.

Topological kink modes are peculiar edge excitations that take place at domain boundaries of magnetic fields inside homogeneous materials. Here, the authors experimentally observe kink magnetoplasmons in a 2D electron gas using custom-shaped strong permanent magnets on top of a GaAs/AlGaAs heterojunction.

Here, Shao et. al attribute the reduction in bone mechano-responsiveness seen in type 2 diabetes to abnormal osteocytic calcium dynamics. They identify reduced SERCA2 pump activity as a mediator of this process and show that rescuing SERCA2 significantly improves bone mechanical adaptation in this context.

Deep-blue emitters and corresponding light-emitting devices are still in the progress to meet industrial standards. Here, the authors report catalytic interconversion of isomeric iridium(III) complexes and achieve true-blue emission and operational half-lifetime of over 10,000 h for tandem devices.

Cryo-electron microscopy structures of three different serotonin receptors in complex with serotonin and other agonists provide insights into the role of lipids in regulating these receptors and the structural basis of ligand recognition.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

PSR J1953+1844 (M71E) has an orbital period of 53.3 minutes and a companion with a mass of 0.07 M_⊙, making it a bridging object between redbacks and black widows in the evolutionary track.

Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target:  the protein–protein interaction (PPI) of GIT1/β-Pix.

Here, a draft sequence of the giant panda genome is assembled using next-generation sequencing technology alone. Genome analysis reveals a low divergence rate in comparison with dog and human genomes and insights into panda-specific traits; for example, the giant panda's bamboo diet may be more dependent on its gut microbiome than its own genetic composition.

Lithium-rich layered oxides are promising cathode materials for next-generation batteries, but they suffer from long-standing problems such as voltage decay during cycling. Here the authors analyse the root cause of voltage decay and present a structure engineering strategy to mitigate the issue for a cobalt-free, lithium-rich layered oxide.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

E-skins often have poor interfaces that lead to unstable performances. Here, authors report e-skins with a quasi-homogeneous composition and bonded micro-structured interfaces, through which both the sensitivity and stability of the devices are improved.

3D printing pore-free complex metal parts remains a challenge. Here, the authors combine in-situ imaging and simulations to show thermocapillary force can eliminate pores from the melt pool during a laser powder bed fusion process.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

A new strategy to separate radioactive americium from lanthanides based on complexation with polyoxometalates and ultrafiltration technique is highly efficient and rapid, does not involve any organic components and requires minimal energy input.

Glycerol flux across the plasma membrane is critical to metabolism and linked to disease. Here, authors present the cryo-EM structure of the glycerol channel AQP7 composed of two adhering tetramers and displaying well-defined densities in the central pore.

A metasurface is used to generate a hybrid grafted perfect vector vortex beam, which can be dynamically controlled with a half waveplate. The beam has spatially variant rates of polarization change due to the involvement of more topological charges.

A quest to resolve ultra-high vacuum synthesis of high-quality, single-crystalline metal oxide thin films containing hard-to-oxidize metals reveals a hidden role of epitaxial strain on the metal oxidation chemistry and resulting thin-film growth.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

Whether a polymorphic transition exists in high entropy alloys or not remains unclear since discovery of these alloys more than a decade ago. Here authors report an irreversible polymorphic transition fromfcc to hcp in the prototype FeCoCrMnNi high entropy alloy and provide evidence for fccphase being more stable than hcp phase only at high temperatures.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Enhancing the intrinsic activity and space time yield of Cu based heterogeneous methanol synthesis catalysts is one of the major topics in CO₂ hydrogenation. Here the authors develop a highly active inverse catalyst composed of fine ZrO₂ islands dispersed on metallic Cu nanoparticles.

Designing energy efficient and scalable artificial networks for neuromorphic computing remains a challenge. Here, the authors demonstrate tree-like conductance states at room temperature in strongly correlated perovskite nickelates by modulating proton distribution under high speed electric pulses.

Non-orthogonal magnetization switching is related to the shear strain associated with ferroelectric domains, with implications for magnetoelectric devices.

According to conventional wisdom, angle-resolved photoemission spectroscopy (ARPES) can only measure the magnitude of the superconducting gap but not its phase. Here, the authors propose a new method to directly detect the superconducting gap phase using ARPES and validate this technique on a cuprate superconductor.

Low-frequency DNA variants can be detected via low-depth multiplexed sequencing after their amplification using polymerase chain reaction and rationally designed ‘blocker’ oligonucleotides.

The carbon and energy efficiencies of current CO₂/CO electrolysis systems are limited. Here the authors show that these metrics can be improved by controlling ion flows in the vicinity of a copper catalyst by the application of a covalent organic framework.

Treg cells can be functionally altered by epigenetic modulators. Here the authors show that the histone H3K36 methyltransferase Setd2 is important for the survival of Treg cells and for the regulation of IL-33 mediated Th2 responses in mice and SETD2 expression is increased in Treg cells from human colorectal cancer tissue.

Here, the authors show that TRIM28-mediated SUMOylation of SARS-CoV-2 NP is critical for its liquid-liquid phase separation (LLPS) property and subsequent inhibition of innate antiviral immunity. The peptide NSIP-III is applied to unleash such connection by interfering TRIM28 and NP interaction.

Vasoactive intestinal polypeptide receptor (VIP1R) is a widely expressed class B G protein-coupled receptor and a drug target for the treatment of inflammatory diseases. Here authors report a cryoelectron microscopy structure of human VIP1R bound to PACAP27 and Gs heterotrimer, which provides insights into PACAP27 binding and VIP receptor activation.

Machine learning is a powerful tool for screening electrocatalytic materials. Here, the authors reported a seamless integration of machine-learned physical insights with the controlled synthesis of structurally ordered intermetallic nanocrystals and well-defined catalytic sites for efficient nitrate reduction to ammonia.

Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

A major challenge in magnon based approaches to information processing lies in developing valves to allow or supress the magnon signal. Here, Chen et al demonstrate a van der Waals magnet based magnon valve which can be tuned electrically over an exceptionally wide range.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

The critical temperature of single-layer FeSe films is much higher than the bulk of other iron-based superconductors, but the mechanism for this is unclear. Adding to the puzzle, Liu et al.show that it is much more difficult to induce superconductivity in a double-layer FeSe film than a single layer.

Metallic oxide SrNbO₃has been identified as an efficient hydrogen evolution photocatalyst. Here, Venkatesan and co-workers show that its visible light absorption stems from plasmon resonance, thanks to its large carrier density (despite a large 4.1 eV bandgap), as opposed to from an interband transition.

Researchers demonstrate coherent X-ray surface scattering imaging in a grazing-incidence geometry that takes advantage of enhanced X-ray surface scattering and interference near total external reflection. Surface patterns are reconstructed in three dimensions with nanometre resolution. The approach has applications in the analysis of buried nano-electronic and nanophotonic structures.