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Showing 1–10 of 10 results
Advanced filters: Author: X. Sharon Hu Clear advanced filters

  • It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

    • Mitchell J. Machiela
    • Weiyin Zhou
    • Stephen J. Chanock
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • A pangenome analysis of 76 wild and domesticated barley accessions in combination with short-read sequence data of 1,315 barley genotypes indicates that allelic diversity at structurally complex loci may have helped crop plants to adapt to agricultural ecosystems.

    • Murukarthick Jayakodi
    • Qiongxian Lu
    • Nils Stein
    ResearchOpen Access
    Nature
    Volume: 636, P: 654-662

  • Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

    • Kevin B Jacobs
    • Meredith Yeager
    • Stephen J Chanock
    Research
    Nature Genetics
    Volume: 44, P: 651-658

  • Sirtuins are NAD+-dependent deacylases implicated in the regulation of stress responses, bioenergetics and epigenetic control. Here the authors describe the crystal structure of a sirtuin-activating compounds (STAC)-sirtuin complex and begin to elucidate the mechanism of sirtuins activation by STACs.

    • Han Dai
    • April W. Case
    • James L. Ellis
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Li and colleagues report that c-Abl regulates the responses downstream of bone morphogenetic protein (BMP) that direct proliferation or senescence in osteoblasts. They show that phosphorylation of the BMP receptor BMPR1A by c-Abl promotes downstream Smad-mediated responses and osteoblast expansion, whereas in the absence of c-Abl, BMP activates Erk signalling, leading to p16INK4a-induced senescence.

    • Hui-Yi Kua
    • Huijuan Liu
    • Baojie Li
    Research
    Nature Cell Biology
    Volume: 14, P: 727-737

  • Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • Qin Li
    • Jin Billy Li
    Research
    Nature
    Volume: 550, P: 249-254

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57