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Advanced filters: Author: Xavier Pascal Berney Clear advanced filters

  • CDK4/6 inhibitors (CDK4/6i) have improved cancer patient outcomes but shown limited benefits for those with triple-negative breast cancer (TNBC). Here, the authors report that CDK4/6 inhibition prevents CDK4 enhanced mitochondria-endoplasmic reticulum interactions, inhibiting mitochondrial apoptosis and driving resistance to CDK4/6i in TNBC models.

    • Dorian V. Ziegler
    • Kanishka Parashar
    • Lluis Fajas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23