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Showing 1–5 of 5 results
Advanced filters: Author: Xi-Juan Liu Clear advanced filters

  • Two epigenetic regulators—identified in an RNA interference screen in Caenhorhabditis elegans, and conserved in mammals—diminish mitochondrial function and accelerate the age-related deterioration of behaviour.

    • Jie Yuan
    • Si-Yuan Chang
    • Shi-Qing Cai
    Research
    Nature
    Volume: 579, P: 118-122

  • Identifying the gene polymorphisms that are the foundations of variation in glia–neuron signalling in Caenorhabditis elegans provides insight into highly variable age-related declines in worm behaviours.

    • Jiang-An Yin
    • Ge Gao
    • Shi-Qing Cai
    Research
    Nature
    Volume: 551, P: 198-203

  • Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.

    • Qiang Jiang
    • Kai Li
    • Shi-Qing Cai
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.

    • Ling Zhao
    • Xiang-Jun Chen
    • Kang Zhang
    Research
    Nature
    Volume: 523, P: 607-611